Barcelona will meet Manchester United in the Champions League quarter-finals following the draw on Friday while Manchester City face Tottenham Hotspur in an all-Premier League clash.
Manchester United enjoyed perhaps their finest performance.
The English title race will go down to the the two teams battled out a pulsating and ultimately ill-tempered 2-2 draw at Highbury.
Images from the English Premier League matches played on Sunday
Manchester United opened up an eight point lead at the top of the Premier League -- at least until second-placed Manchester City playing at Arsenal later -- when they beat 10-man Queens Park Rangers 2-0 at Old Trafford on Sunday.
Louis van Gaal found no instant fix for Manchester United as a new era dawned at Old Trafford with a dispiriting 2-1 opening-day home defeat by Swansea City in the Premier League on Saturday.
Two goals from Cesc Fabregas gave Arsenal a routine 2-0 victory over precariously placed Middlesbrough Sunday to extend their unbeaten sequence in the Premier League to 20. Captain Fabregas and his team mates were in a different class to Boro as they closed the gap on third-placed Chelsea to six points with four games remaining although they are 12 points behind leaders Manchester United.
Manchester United moved to the top of the Premier League with a comfortable 2-1 win over Arsenal, a match that saw striker Robin van Persie face his old side for the first time.
Manchester United moved to the top of the Premier League with a comfortable 2-1 win over Arsenal, a match that saw striker Robin van Persie face his old side for the first time.
Man Utd sign Mount from Chelsea on five-year deal
Manchester United and Chelsea pulled ahead of Arsenal while Liverpool dropped out of the running in the race for the Premier League title.
Chelsea have topped the spending list with Manchester United not far behind, but West Ham United's business epitomises the TV riches which give all Premier League clubs spending power that only the elite teams in Spain or Germany can dream of.
A round-up of Saturday's action in the Premier League.
Arsenal launched their bid for a first Premier League crown in five years with a comfortable 1-0 win over promoted West Bromwich Albion on the opening day of the season on Saturday. Liverpool, who have their eyes on a first title since 1990, also got off to a winning start by beating Sunderland 1-0 at the Stadium of Light with a late goal from Fernando Torres.
Images from the English Premier League matches played across England on Sunday.
Reading snatched a 1-1 draw at Manchester United while Chelsea trounced Norwich City 4-0 to reach the FA Cup quarter-finals.
The "noisy neighbours" have been generally a bit quieter in recent weeks and should Manchester United beat Manchester City at Old Trafford on Saturday their title claims will be just about silenced.
Nine-times winners Real Madrid will play Manchester United in the last 16 of the Champions League after the draw was made at UEFA's headquarters in Switzerland on Thursday.
Manchester United finished with nine men in a 1-0 defeat at Everton on Wednesday.
Leicester City were left in touching distance of a fairytale first Premier League title on Sunday after Leonardo Ulloa's double helped them outclass Swansea City at a delirious King Power Stadium.
Wayne Rooney will have George Best's goalscoring tally in his sights when he tries to help Manchester United take a stranglehold on the Premier League title race at home to Queens Park Rangers on Sunday (1230 GMT).
United are 16th in the standings with a game in hand heading into the international break.
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Arsenal are brimming with confidence after beating Liverpool but they will have to show consistency to overcome in-form Porto in the Champions League last 16.
Manchester United manager David Moyes criticised referee Howard Webb for not giving his side a late penalty as their revival ended in a 2-1 home defeat by Tottenham Hotspur in the Premier League on Wednesday.
Manchester City passed their first major test of the season on Saturday with flying colours by beating Arsenal 4-2 to make it four wins out of four. Champions Manchester United recovered from conceding an early goal at Tottenham Hotspur to win 3-1 even though Paul Scholes was sent off after an hour.
The former beat Leeds United 4-1 while Manchester United got the better of Aston Villa 2-1 in the third round of the FA Cup.
Arsenal rediscovered their Premier League form on Saturday with a convincing 3-0 victory over Newcastle United at the Emirates Stadium. Portsmouth ended a run of six successive league defeats when they won 3-0 at Everton while Hull City's flying start ended emphatically when they were thrashed 5-0 at home by Wigan Athletic.
Images from the English Premier League London derby played between Arsenal and Chelsea at the Emirates on Wednesday
Arsenal inflicted Liverpool's sixth Premier League defeat of the season with a 2-1 victory on Sunday, their first league win at Anfield since 2003.
How could a front six including Angel Di Maria, Robin van Persie, Wayne Rooney and Juan Mata fail to get a single shot on target in a 1-0 home defeat by Southmapton?
Saturday's clash between Manchester United and Tottenham Hotspur at Old Trafford is already shaping up as an early-season eliminator to challenge runaway leaders Manchester City for the Premier League title.
They crushed Charlton Athletic to move eight points clear of Arsenal at the top of the English premiership.
Arsenal stayed top of the Premier League after two goals in five minutes from Spain international midfielder Santi Cazorla set them on their way to a 2-0 win over Fulham who remain mired deep in the relegation battle.
Asked whether he will make his debut against Arsenal in the Premier League on Sunday, the 28-year-old said that he has been training throughout the pre-season and "feels good".
IMAGES from the English Premier League match played on Saturday
Chelsea moved two points clear at the top of the Premier League with a 2-0 defeat of Liverpool at Stamford Bridge on Sunday.
A first-half Robert Pires goal earned them victory over Southampton.
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